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notch

The Notch signaling pathway is a highly conserved cell signaling system present in most animals. Mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, non-covalent interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region.Notch signaling promotes proliferative signaling during neurogenesis, and its activity is inhibited by Numb to promote neural differentiation. It plays a major role in the regulation of embryonic development.

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  1. RogerDis

    What is the notch for?

    Can anyone tell me why there is a notch on the back of this toilet cistern, please? All that it has achieved so far is to encourage mould to grow on the wall behind it! I've never seen anything like it before.
    • RogerDis
    • Thread
    • america cistern notch usa
    • Replies: 2
    • Forum: USA
  2. S

    lets all design a boiler, top notch components.

    Evening all, I'm currently in the alps snowboarding. I've just had my meal and browsing some recent posts and got me wondering about what is the best boiler on the market, we all have our preferences. After ideals shamble of shat ' isar' I vowed never to touch an ideal again, but I was coaxed in...
  3. M

    New build house 3 joists together notch or drill?

    Hi, I have a 3 floor new build house to first fix that at two places on each floor there are 3 joists but up together. I think due to the staircase. Would/ has any one drilled through with an angled drill 3 joists in a row? Or the other option would be notching But I hear there is strict...
  4. Chalked

    Don't move the bog. Just notch the door!

    Nice cutting!
  5. G

    How NOT to notch or drill joists.....

    As an addition to my free guide to notching and drilling joists that I posted in the Plumbers Forum last week, I thought you'd like to see an example of what NOT to do and I come across this a lot. The photos are from a bathroom install that I started today and the joists had been cut in half...
  6. Dan

    ContractorForum: What notch to use: Guys I need some advice please on what type and s

    ContractorForum: What notch to use: Guys I need some advice please on what type and size of trowel to use for the following: (pl.. http://bit.ly/8k2wpD More... Follow us on Twitter.
  7. Dan

    ContractorForum: Trowel notch size confusion !!: I've been advised on here I need a 1

    ContractorForum: Trowel notch size confusion !!: I've been advised on here I need a 10mm half moon adhesive trowel to lay my 610.. http://bit.ly/7EfvbK More... Follow us on Twitter.
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