As long as you have a decent head on pipework you're working on and that there isn't a massive high spot you'll always clear the air. Typically pipes go in notched into the joists at the same depth regardless of what the spirit level says.
The only time I've ever struggled with air locking hot...
See if you can get a measurement on the cut out underneath and fingers crossed your current sink just has a bigger flange
Alternatively if you have space to open the hole up further and a big base unit you could stick a double in...
If you can find something that will create a waterproof seal and then be sufficient to stick what ever your tiles/wall panels too then sure. Most installations don't have any tanking but that isn't to say that is the right thing to do.
Currently first fixing for 25 of those. 15 being re-finished and 10 new ones. Biggest being 800x 1500 at 150kg. Let me know how they go as not had to do any cast iron rads yet. Mine are also set to be delivered in 2 parts for the big ones but didn't realise I would need fancy tools to assemble...
Get a decent engineer to isolate the boiler and test. It will then be obvious if its the system or the boiler. From that point its fairly easy to figure out. If its the boiler it will likely be the Heat exchanger or the pressure relief, if its the heating system and you're not showing any water...
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